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Using Ultrasound to detect diaphragm dysfunction in patients with acute deterioration of chronic obstructive lung disease and assessing its utility in estimating failure of Non invasive ventilation in such patients

Utility of Ultrasound-assessed diaphragmatic dysfunction in estimating non-invasive ventilation failure of patients with Acute exacerbation of chronic obstructive pulmonary disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/05/025462
Enrollment
60
Registered
2020-05-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J441- Chronic obstructive pulmonary disease with (acute) exacerbation

Interventions

Intervention1: Arterial Blood Gas: recorded at baseline and at least 2, 4, 6, 12, 24, and 48 hours following non invasive ventilation. Intervention2: Lung Ultrasonography: will be performed by a 7- to

Sponsors

None
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Acute exacerbation of chronic obstructive lung disease with acidosis (PaCO2 >45mm Hg, pH <7.25) in need of non-invasive ventilation

Exclusion criteria

Exclusion criteria: 1. Patients with acute pulmonary edema. 2. History of interstitial lung disease. 3. History of neuromuscular disease. 4. Chest wall deformities. 5. Previously diagnosed diaphragmatic palsy. 6. Hemodynamic instability (Systolic blood pressure 7. Intracranial hypertension. 8. Pregnancy. 9. Any contraindication to Non-invasive ventilation, 10. Need for immediate endotracheal intubation or invasive mechanical ventilation at ICU admission

Design outcomes

Primary

MeasureTime frame
Non-invasive ventilation (NIV) failure rate with respect to new onset or continuous diaphragmatic dysfunction assessed by ultrasound guided measurement of change in diaphragmatic thickness (Î?TDI).Timepoint: Î?TDI assessed at 2 hrs on NIV or immediately prior to intubation if patient requires intubation before 2 hrs of NIV. NIV failure assessed during ICU stay—

Secondary

MeasureTime frame
Diaphragmatic dysfunction assessed by ultrasound guided measurement of change in diaphragmatic thickness (Î?TDI).Timepoint: At ICU admission;ICU mortality, In hospital mortality and 30 day mortality.Timepoint: ICU admission (Day 1) to 30 days follow up or death whichever is earlier.;In hospital length of stay.Timepoint: ICU admission (Day 1) to patient discharge or death or 30 days whichever is earlier.;Length of stay in ICU.Timepoint: ICU admission ( Day 1) to patients ICU discharge or death or 30 days whichever is earlier;Time to NIV failure.Timepoint: ICU admission (Day 1) to time point of intubation.;Ventilation days (invasive).Timepoint: Duration of invasive ventilation;Ventilation days (Non - invasive).Timepoint: Duration of non-invasive ventilation—

Countries

India

Contacts

Public ContactDr Gaurav Jain

AIIMS RISHIKESH

gauravhld@gmail.com8808631209

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026