Branched Chain Amino Acid and Muscle mass in Chronic Liver Disease

Effect of branched chain amino acids supplementation on muscle mass, muscle quality and molecular markers of muscle regeneration in patients with chronic liver disease-A Randomized Controlled Trial. - BCAA Trial

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/05/025459

Enrollment

Registered

2020-05-29

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver

Interventions

Intervention1: Intervention Group : Branched Chain Amino Acid: The patients would receive customized diet charts providing 30-35Kcal/ideal body wt/day and 1.5 gm protein/ideal body wt/day. Dietary Sup

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with decompensated cirrhosis (CTP 7-9) of all etiologies 2. Age: 18-60yrs 3. Hemostatically stable patients with platelet >80000 4. INR 5. Who give consent for muscle biopsy 6. BMI

Exclusion criteria

Exclusion criteria: 1. Presence of overt hepatic encephalopathy 2. Patients with co-morbidities like acquired immunodeficiency syndrome, HCC, Other cancer, diabetes mellitus, chronic kidney disease, congestive heart disease, chronic respiratory disease 3. Patients continuing to take alcohol in past 3 months 4. Patients with transjuglar intrahepatic portosystemic shunt [TIPS] 5. Patients on steroids 6. INR >2.5 7. Refusal to participate in the trial

Design outcomes

Primary

Measure	Time frame
Improvement in the muscle massTimepoint: 3 months	—

Secondary

Measure	Time frame
Changes in the molecular markers of muscle regenerationTimepoint: 3 months;Improvement in the functional capacity of the patientsTimepoint: 3 months;Improvement in the muscle qualityTimepoint: 3 months;Improvement in the nutritional statusTimepoint: 3 months	—

Countries

India

Contacts

Public ContactDr Jaya Benjamin

Institute of Liver and Biliary Sciences

jayabenjaminilbs@gmail.com9540951081

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026