Comparision of the efficacy of buffered lignocaine hydrochloride with adrenaline over lignocaine hydrochloride with adrenaline on pain during injection, onset and duration of anaesthesia in inferior alveolar nerve block.

Comparision of the efficacy of 7.5% sodium bicarbonate and lignocaine hydrochloride with adrenaline over lignocaine hydrochloride with adrenaline on pain during injection, onset and duration of anaesthesia in inferior alveolar nerve block: a randomized clinical trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/05/025405

Enrollment

100

Registered

2020-05-28

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Buffering of local anaesthesia: 7.5% sodium bicarbonate and lignocaine hydrochloride with adrenaline. buffered anaesthesia contains 1:10 ratio of 2%lignocaine hydrochloride with 1:80,0

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients that wish to undergo mandibular tooth extractions 2.Patients who fall in the age group of 18-60 years 3.Patients who do not give subjective symptoms after administration of local anesthetic solution

Exclusion criteria

Exclusion criteria: 1.Patients taking any medications that would alter pain perception 2.Patients who are medically compromised or those with systemic illnesses 3.Pregnant or lactating women 4.Patients who have contraindications for lignocaine with adrenaline administration

Design outcomes

Primary

Measure	Time frame
Analyse the effect of adding 7.5% sodium bicarbonate to the local anaesthetic solution on: 1.Pain during injection 2.Onset of anaesthesia 3.Duration of anaesthesia Timepoint: 24 hours maximum	—

Secondary

Measure	Time frame
Compare the efficacy of buffered lignocaine hydrochloride with adrenaline and lignocaine hydrochloride with adrenalineTimepoint: 24 hours maximum	—

Countries

India

Contacts

Public ContactDr Palak Agrawal

Chhattisgarh Dental College And Research Institute, Rajnandgaon

rajdeepsinghdurg@gmail.com07587101121

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026