To study heart rate and blood pressure changes after use of two drugs like propofol and ketofol used for giving general anaesthesia

Comparison of haemodynamic responses following induction of general anaesthesia with propofol versus ketofol

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/05/025380

Enrollment

Registered

2020-05-27

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E049- Nontoxic goiter, unspecified

Interventions

Intervention1: Ketamine: Other group will receive propofol 1mg/kg body weight and ketamine 1mg/kg body weight intravenously at induction of general anaesthesia Control Intervention1: Propofol: One gro

Eligibility

Inclusion criteria

Inclusion criteria: ASA PS â?? I and II Mallampatti score 1 and 2 Surgeries lasting for 2-3 hours

Exclusion criteria

Exclusion criteria: Anticipated difficult airway Psychiatric illness H/o Emergence delirium following ketamine administration H/o Allergy to ketamine and propofol

Design outcomes

Primary

Measure	Time frame
To compare the changes in heart rate at 3 minutes after induction of general anaesthesia with propofol versus a combination of ketamine and propofol in patients undergoing surgical proceduresTimepoint: 3 minutes after induction	—

Secondary

Measure	Time frame
Comparison of changes in mean arterial pressure, incidence of hypotension or hypertension after induction, time taken for loss of verbal response, level of sedation at the time of extubation, presence or absence of emergence delirium at the end of surgery, total propofol and intraop fentanyl consumption.Timepoint: At pre induction, after induction and at 1,3,5,10 minutes after intubation, time required for loss of response to verbal commands, total propofol and intra op fentanyl consumption, sedation score at 10 minutes and 30 minutes post op	—

Measure

Time frame

Comparison of changes in mean arterial pressure, incidence of hypotension or hypertension after induction, time taken for loss of verbal response, level of sedation at the time of extubation, presence or absence of emergence delirium at the end of surgery, total propofol and intraop fentanyl consumption.Timepoint: At pre induction, after induction and at 1,3,5,10 minutes after intubation, time required for loss of response to verbal commands, total propofol and intra op fentanyl consumption, sedation score at 10 minutes and 30 minutes post op

—

Countries

India

Contacts

Public ContactDr Niranjan Kumar

Amrita Institute of Medical Sciences

suneil71@gmail.com9447464652

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026