Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere
Conditions
Interventions
Intervention1: Losartan: Losartan 25mg given twice a day till discharge or outcome.
Control Intervention1: Placebo: Given twice a day in same schedule as intervention till discharge or outcome
Sponsors
Sanjay gandhi Post Graduate Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age > 18 years 2. Requirement of hospitalization 3. Randomization within 24 hours of initial presentation to a hospital/diagnosis
Exclusion criteria
Exclusion criteria: 1. Currently taking an angiotensin converting enzyme inhibitor (ACEi) or Angiotensin receptor blocker (ARB) 2. Prior reaction or intolerance to an ARB or ACEi 3. Blood pressure less than 100/70 mmHg 4. Potassium great than 5.0 mEq/L 5. Pregnancy or breastfeeding In females of childbearing age, unwillingness to use birth control for the duration of the study 6. Estimated Glomerular Filtration Rate (eGFR) of 7. AST and/or ALT > 3 times the upper limit of normal 8. Severe volume depletion or severe acute kidney injury that, in the opinion of the investigator, would preclude administration of Losartan 9. Concurrent treatment 10. Inability to obtain informed consent 11. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patient with treatment failure: Treatment failure defined as any of following after 48 hours of randomization i) A Fall in 1 score in Respiratory SOFA score ii) New requirement of respiratory assist devices (HFNC, NIV) iii) New requirement of mechanical ventilation iv) MortalityTimepoint: Percentage of patient with treatment failure: Treatment failure defined as any of following after 48 hours of randomization i) A Fall in 1 score in Respiratory SOFA score ii) New requirement of respiratory assist devices (HFNC, NIV) iii) New requirement of mechanical ventilation iv) Mortality | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. 28-Day Mortality 2. Change in SOFA score 3. Worsening of ARDS categories 4. Respiratory Failure requiring Mechanical Ventilation 5. Length of Hospital Stay 6. ICU Admission 7. ICU Length of StayTimepoint: 28 days. Continuous assessment for respiratory failure requiring ventilator, change in SOFA score, need for ICU admission. | — |
Countries
India
Contacts
Public ContactDr Able Lawrence
Outcome results
None listed