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Hypotension during sinus surgeries to decrease intraoperative bleeding using either of two drugs as comparison - dexmedetomidine and propofol

Controlled hypotension during Functional endoscopic sinus surgery-a comparative evaluation between propofol and dexmedetomidine infusion

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/05/025304
Enrollment
40
Registered
2020-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J329- Chronic sinusitis, unspecified

Interventions

Intervention1: Dexmedetomidine infusion: For controlled hypotension during functional endoscopic sinus surgery- dexmedetomidine infusion @ 0.2-0.5 mcg/kg/hr intravenous throughout the duration of the

Sponsors

IPGMER and SSKM Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Randomly selected patients admitted in ENT ward with nasal pathology belonging to ASA I or II willing to give written consent

Exclusion criteria

Exclusion criteria: Pregnant and breast feeding women Pre existing cardiac disease, renal disorder, hepatic disease and psychiatric disorder Patient refuses to participate History suggestive of any coagulation disorder, diabetes mellitus, alcoholism, neuromuscular/neurological disorder History of allergy to drugs Any other contraindications for using propofol and dexmedetomidine

Design outcomes

Primary

MeasureTime frame
mean blood loss and operative field visibilityTimepoint: beginning to end of surgery—

Secondary

MeasureTime frame
Adverse effectsTimepoint: beginning to end of surgery;Blood lactate level at the end of controlled hypotensionTimepoint: beginning to end of surgery;Cerebral oxygen saturationTimepoint: beginning to end of surgery;Duration of surgeryTimepoint: beginning to end of surgery;Haemodynamic parametersTimepoint: beginning to end of sugery—

Countries

India

Contacts

Public ContactDr Sankari Santra

IPGMER

sankarisantra@yahoo.com9830383874

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026