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Comparison of single breath with breath holding Vs three breath for anaesthesia with sevoflurane in adults by BIS monitoring: A prospective randomized study

Comparison of single vital capacity breath with breath holding Vs three vital capacity breath induction with sevoflurane in adults by BIS monitoring: A prospective randomized study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/05/025303
Enrollment
80
Registered
2020-05-22
Start date
Unknown
Completion date
Unknown
Last updated
2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K811- Chronic cholecystitis Health Condition 2: N971- Female infertility of tubal origin Health Condition 3: C569- Malignant neoplasm of unspecifiedovary Health Condition 4: H654- Other chronic nonsuppurative otitis media

Interventions

Intervention1: sevoflurane induction: single breath with breath holding for 20 seconds versus three breath induction with sevoflurane in adults , inhalational route with minimum alveolar concentratio

Sponsors

Department of anaesthesia
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Cooperative Individuals ASA I and II Elective ENT and urological, orthopaedic and visceral surgery

Exclusion criteria

Exclusion criteria: Children 50 yrs Uncooperative patients and not willing ASA III and above Pregnant patients Allergy and sensitive to volatile anesthetics Emergency surgical patients Adults with contraindication to inhalational induction of anesthesia ( gastro-esophageal reflux disease, vomiting, full stomach, myopathy or family history of malignant hyperthermia) H/O cardiac dysfunction, epilepsy, neurological disease , asthma, severe or acute respiratory illness or infection during the previous week Smokers and preexisting organ dysfunction

Design outcomes

Primary

MeasureTime frame
Induction with single vital capacity breath with breath holding or three vital capacity breath using sevofluraneTimepoint: loss of eyelash reflex, return of conjugate gaze after 20 seconds of inhalation of sevoflurane

Secondary

MeasureTime frame
compare the efficacy between single breath with breath holding and three breath group, assess the depth of induction with bisspectral indexTimepoint: bispectral index value between 60-40 is considered as adequate depth up to 90 seconds after administration of sevoflurane

Countries

India

Contacts

Public ContactVYSHNAVI RENGANATHAN

ESIC MEDICAL COLLEGE AND HOSPITAL

sksdhanalakshmi@gmail.com7893720606

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026