Health Condition 1: F312- Bipolar disorder, current episodemanic severe with psychotic features
Conditions
Interventions
Intervention1: Folic acid: Dose- 5 mg
Frequency- Once daily
Route- Oral
Duration- 6 weeks
Control Intervention1: NOT APPLICABLE: NOT APPLICABLE
Sponsors
Central Institute of Psychiatry
Eligibility
Inclusion criteria
Inclusion criteria: 1. Inpatients satisfying the ICD 10-DCR [1993] criteria for Bipolar affective disorder, current episode manic with psychotic symptoms with YMRS score of >20. 2. Age group of 18-50 years of either sex. 3. Drug naive patients or drug free for minimum 2 weeks on mood stabilisers/antipsychotics and 4 weeks for depot antipsychotics. 4. Patients started on second generation antipsychotics and any mood stabilizer except those affecting folic acid levels. 5. Those who give informed consent for participating in the study.
Exclusion criteria
Exclusion criteria: 1. Any other major co-morbid psychiatric diagnosis and substance dependence excluding nicotine & caffeine. 2. Significant medical or neurological illness including severe cardiovascular, hepatic, renal, [serum creatinine > 1.5 mg/dl], anaemia [Haemoglobin 3. Pregnancy 4. BMI >30 kg/m2 5. Not willing to give written informed consent 6. Known hypersensitivity to FOLIC ACID or any of its components 7. Any current systemic infection/ inflammation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effect of folic acid on the levels of homocysteineTimepoint: Baseline, 2 weeks and 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the correlation of changes in YMRS, BPRS & CGI with socio-demographic, clinical and laboratory parameters in patients receiving folic acid and those not receiving folic acid.Timepoint: Baseline, 2 weeks and 6 weeks | — |
Countries
India
Contacts
Public ContactDR PRANJAL DEY
Department of Psychiatry
Outcome results
None listed