Effect of positive pressure ventilation and its postoperative efficiency in laparoscopic uterus removal surgeries under General Anaesthesia

Effect of intraoperative high PEEP with recruitment maneuver versus no PEEP on postoperative pulmonary complications in laparoscopic hysterectomy surgeries under general anaesthesia - A Randomized Control Study

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/05/025168

Enrollment

Registered

2020-05-14

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z758- Other problems related to medicalfacilities and other health care

Interventions

Intervention1: PEEP (Positive End Expiratory Pressure) and Recruitment maneuver: Patients will be ventilated on volume-controlled mechanical ventilation with a tidal volume of 8 mL/kg of predicted bod

Eligibility

Inclusion criteria

Inclusion criteria: ASA I-II Elective Surgeries Laparoscopic Assisted Vaginal Hysterectomy(LAVH) and Total Laparoscopic Hysterectomy(TLH) surgeries Surgical duration more than 1 hours

Exclusion criteria

Exclusion criteria: Emergency surgeries Patients converted to open hysterectomy surgeries. severe chronic obstructive pulmonary disease severe pulmonary hypertension Renal Insufficiency (Creatinine > 1.8) Hepatic Insufficiency ( Direct Bilirubin > 2.0) Patients with Cardiac complication Patients with Neurological complication

Design outcomes

Primary

Measure	Time frame
To evaluate the postoperative pulmonary oxygen efficiency- PaO2 and PaO2/FiO2 ratio.Timepoint: 6 hours after the surgery	—

Secondary

Measure	Time frame
Intraoperative haemodynamics variation, alveolar-arterial oxygen gradient, postoperative PFT and postoperative pulmonary complications like atelectasis, pneumothorax and mechanical ventilator support. Timepoint: Intraoperative haemodynamics variation during surgery period , alveolar-arterial oxygen gradient after 6 hours of surgery, postoperative PFT on POD-3 and postoperative pulmonary complications like atelectasis, pneumothorax within 24 hours of surgery and need mechanical ventilator support till POD-3.	—

Measure

Time frame

Intraoperative haemodynamics variation, alveolar-arterial oxygen gradient, postoperative PFT and postoperative pulmonary complications like atelectasis, pneumothorax and mechanical ventilator support. Timepoint: Intraoperative haemodynamics variation during surgery period , alveolar-arterial oxygen gradient after 6 hours of surgery, postoperative PFT on POD-3 and postoperative pulmonary complications like atelectasis, pneumothorax within 24 hours of surgery and need mechanical ventilator support till POD-3.

—

Countries

India

Contacts

Public ContactDr Swetha Ramani

SRM Institute of Science and Technology( Deemed to be University)

gayathrii.r@gmail.com9500092905

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026