Comparison between response of one drug and response of two drugs together in treating fungal keratitis

Comparative Evaluation Of Monotherapy Vs Combination Therapy In Fungal Keratitis

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/05/025159

Enrollment

Registered

2020-05-13

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: Natasol,Natamycin,Voriconazole: Group 1 receives topical Natamycin suspension 5 % Group 2 receives topical Natasol[1% soluble Natamycin] Group 3 receives topical Natamycin 5% and topica

Eligibility

Inclusion criteria

Inclusion criteria: Age 18 yrs and older KOH smear positive fungal infection Ulcer size willing to give Informed Consent willing for follow up

Exclusion criteria

Exclusion criteria: Keratitis other than Fungus B/L corneal ulcer Pregnant /Lactating females Impending perforation Perforated corneal ulcer Received prior treatment

Design outcomes

Primary

Measure	Time frame
Best Corrected Visual AcuityTimepoint: Best Corrected Visual Acuity at 3 months	—

Secondary

Measure	Time frame
Duration of healing Scar size Percentage of healed keratitisTimepoint: at 3 months	—

Countries

India

Contacts

Public ContactDr Challa Divya Vani

Dr. Rajendra Prasad Centre for Ophthalmic Sciences

namrata.sharma@gmail.com9101126593144

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026