None listed
Conditions
Interventions
Intervention1: Nor-epinephrine infusion compared with normal saline infusion (placebo group): Saline solutions (plain in Group C and containing norepinephrine in Group NE were on standby and infusion
Sponsors
Nizams Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients of ASA I class (American society of Anaesthesiology), in age group of 18 to 55 years and those assigned for elective, lower limb surgery under only spinal anaesthesia and requiring use of tourniquet will be included.
Exclusion criteria
Exclusion criteria: Patients need to be excluded will be- 1. ASA II to IV 2. Multiple comorbidities 3. Patients with hypertension and diabetes, morbid obesity 4. Patients on cardiovascular medications including calcium channel blockers, angiotensin convertase inhibitors, Beta or a blocking drugs. 5. Patients with arterial disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome: the study primary outcome targets prevention and/or amelioration of the hypotension induced by SAB and tourniquet releaseTimepoint: starting of spinal anaesthesia to 10 min after stoppage of nor epinephrin infusion . | — |
Secondary
| Measure | Time frame |
|---|---|
| : this included proper adjustment of rate and duration of infusion to obtain minimal intraoperative heart rate and blood pressure fluctuation, and minimising other manifestations of SAIH (Spinal anaesthesia Induced Hypotension) such as nausea and vomiting during surgery.Timepoint: Following spinal anaesthesia and continued till 10 minutes after tourniquet release, Infusion doses will be tapered gradually and blood pressure readings will be noted for 10 minutes after stoppage. | — |
Countries
India
Contacts
Public ContactAbinash Patro
Nizams Institute of Medical Sciences
Outcome results
None listed