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Comparing the efficacy of two anesthetic solutions namely lignocaine and Ropivacaine during endodontic procedures such as root canal treatment

Comparison of anesthetic efficacy of Ropivacaine and Lignocaine in patients with irreversible pulpitis: A double-blind randomized clinical trial.

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/05/025110
Enrollment
60
Registered
2020-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R52- Pain, unspecified

Interventions

Intervention1: Lignocaine 2% with 1:80,000 epinephrine: The gold standard anesthetic solution used in dentistry Control Intervention1: 0.5% Ropivacaine: The long acting anesthetic which is compared wi

Sponsors

SThendral
Lead Sponsor
Rajas Dental College and Hospital
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: . Subjects with age range between 18 to 50 years. 2. Subjects who were currently experiencing active pain in mandibular molars. 3. Subjects without any systemic conditions. 4. Participants should not be under any medications that would alter pain perception and 5.The subjects should be clinically diagnosed with irreversible pulpitis, determined by spontaneous pain and prolonged response to cold testing with Endofrost (Coltene-Roeko) and a positive response to electric pulp testing, with absence of any periapical radiolucency on radiographs except for a mild widening of periodontal ligament space and a vital coronal pulp on access opening. 6. Every subject had atleast one opposing or contralateral molar without any deep coronal restoration, extensive caries, periodontal disease, which was used as a control while pulp testing.

Exclusion criteria

Exclusion criteria: . Patients with systemic conditions, 2. Pregnant and Lactating women, 3. Mandibular molars with periapical radiolucency, 4. Mandibular molars without vital pulp tissue were later excluded during endodontic procedures

Design outcomes

Primary

MeasureTime frame
Pain analysed using visual analogue scale 0-4mm ââ?¬â?? No pain 5-44mm ââ?¬â?? Mild pain 45-74mm ââ?¬â?? Moderate pain 75-100mm ââ?¬â?? Severe pain. These pain ratings were marked by the subjectsTimepoint: 15 mins post - injection.

Secondary

MeasureTime frame
Requirement of supplementary injectionTimepoint: 20 minutes post-injection

Countries

India

Contacts

Public ContactSThendral

Rajas Dental College and Hospital

rajeshgopalv@gmail.com9846048248

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026