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Mechanism of Covid 19 infection in Humans

Putative role of TMPRSS2 a serine protease in the pathogenesis of COVID-19 - TMPRSS2

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/05/024989
Enrollment
200
Registered
2020-05-04
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention1: Blood samples from COVID 19 positive cases who have recovered will be analysed for genetic variability in host factors: Blood samples from COVID 19 positive cases who have recovered wi

Sponsors

Asian HealthCare Foundation
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed with COVID19 admitted in the hospital: -Patients with clinical symptoms such as fever, sore throat and cough and who have been tested positive by RTPCR.

Exclusion criteria

Exclusion criteria: Patients with clinical symptoms of flu tested negative by RTPCR

Design outcomes

Primary

MeasureTime frame
-Identification of variants in host factors ACE2 receptor and Serine protease in COVID 19 patients in India -Mechanism of action of identified variant proteins in viral entry into host cell employing Bioinformatic tools and in vitro testing Timepoint: one year

Secondary

MeasureTime frame
Not ApplicableTimepoint: Not Applicable

Countries

India

Contacts

Public ContactDr M Sasikala

AIG Hospitals

research@aighospitals.com04042444222

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026