Health Condition 1: K50-K52- Noninfective enteritis and colitis
Conditions
Interventions
None listed
Sponsors
Shailesh
Eligibility
Inclusion criteria
Inclusion criteria: Patients with a definite diagnosis of Ulcerative Colitis (UC) or Crohnâ??s Disease (CD) being initiated on azathioprine/6-mercaptopurine/ 6Tioguanine therapy (designated as thiopurine (TP) therapy) as per standard accepted criteria will be included.
Exclusion criteria
Exclusion criteria: 1. Patients with CD or UC on biologicals, or immunosuppressives other than thiopurines 2. Subjects who have undergone total procto-coloctomy for UC 3. Evidence of colorectal dysplasia or malignancies 4. Patients in whom bowel surgery appears to be imminent 5. Congenital or acquired immunodeficiency, especially known HIV infections, or evidence of other immuno-compromised states 6. Patients ineligible in any way for TP therapy e. g. known intolerance to the drug 7. Patients not providing written informed consent for inclusion 8. Planning to conceive in 17weeks after initiation of therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Quantifying Thiopurine metabolites,TPMT,IMPDH,ITPase,HGPRT enzymes using LC-MS/MS 2. Comparision of the metabloites and Enzyme levels in Responders and Non RespondersTimepoint: All at the end of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Quantifying Thiopurine metabolites,TPMT,IMPDH,ITPase,HGPRT enzymes using LC-MS/MSTimepoint: After the initiation of the Therapy | — |
Countries
India
Contacts
Public ContactShailesh
Kasturba Medical College, Manipal Academy of Higher Education
Outcome results
None listed