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To find out whether to use Dopamine or Epinephrine first in Septic Shock in children, who do not respond to fluids

Dopamine versus Epinephrine as the first line inotropic agent in the management of fluid refractory septic shock in children

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/05/024973
Enrollment
40
Registered
2020-05-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R578- Other shock

Interventions

Intervention1: Inotropic agent administration in fluid refractory septic shock in children: Subjects will be randomly assigned to two groups by block randomization i.e. Group A and B. Randomization

Sponsors

Department of Paediatrics
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All children more than 1 month and less than 12 years who present with fluid refractory shock

Exclusion criteria

Exclusion criteria: 1.Patients who have already received any vasoactive drug before PICU admission. 2. Already participated in the trial during the same hospital stay. 3. Patient with a known cardiac disease. 4. Brain dead patients or terminal patients not likely to survive (DNR candidates). 5. Known immune compromised state (malignancy, primary or secondary immunodeficiency). 6. Severe acute malnutrition

Design outcomes

Primary

MeasureTime frame
To compare between Dopamine and Epinephrine for the resolution of shock within the first one hour.Timepoint: 1 hour—

Secondary

MeasureTime frame
1.Resolution of fluid refractory shock during first six hours. 2.Effect on total time to shock resolution. 3.Any complications with any of the drugs (extravasation, arrythmias, ischemia of limb). 4.Calculation of vasopressor inotropic score (VIS) in the patients. 5.Calculation of MOD score i.e Multi Organ Dysfunction Score (PELOD i.e Pediatric Logistic Organ Dysfunction Score) till patient in PICU. 6.Mortality in PICU. Timepoint: 6 hours and then till PICU discharge—

Countries

India

Contacts

Public ContactDr Urmila Jhamb

Maulana Azad Medical College, Delhi

ujhamb@hotmail.com9968604309

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026