Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: B338- Other specified viral diseases
Conditions
Interventions
Intervention1: Niclosamide: 500 mg bid for 7-14 days
Control Intervention1: Standard of care: As per MoHFW, GoI guidelines
Sponsors
Lady Hardinge Medical College
Eligibility
Inclusion criteria
Inclusion criteria: • Adult patients (>=18years) suffering from mild or very mild Covid-19 (8). A positive throat swab for nCoV-2019 (by real time PCR) obtained from a patient suspected to be Covid-19 or from a contact (or HCW) of Covid-19 patient will be considered to be a Covid-19 case, irrespective of the presence of symptoms. Mild disease will be defined as respiratory rate between 12-18/minute and SpO2 >= 95% in room air and no clinico-radiological (normal chest X-ray) signs of pneumonia.
Exclusion criteria
Exclusion criteria: • Patients with renal or hepatic dysfunction (Serum creatinine > 1.5 mg/dL and serum transaminase levels >120 U/L) • Patients with clinical heart failure/known CAD • Known cases of neoplasms or immunodeficiency syndromes • Patients who are on chemotherapy, immunosuppressive agents, steroids or antiviral agents, or have received in the preceding 4 weeks • Pregnant and lactating patients • Uncooperative patients (in the opinion of the investigator, if it is difficult to ensure patient cooperation during the study)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients having virologic cure on Day 6 in both the groupsTimepoint: Day 6 of treatment initiation | — |
Secondary
| Measure | Time frame |
|---|---|
| o Proportion of patients having resolution of symptoms on Day 7 and Day 14 in both the groups o The individual proportion of aforementioned rescue criteria in both the groups. o Side-effects (adverse events) noted in both the groups Timepoint: 7 and 14 days | — |
Countries
India
Contacts
Public ContactAnupam Prakash
LADY HARDINGE MEDICAL COLLEGE
Outcome results
None listed