A clinical trial to study the effects of Entonox gas in labour analgesia in comparison to a placebo oxygen

A Randomised control trial of Entonox and Oxygen in Labour

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/04/024932

Enrollment

200

Registered

2020-04-30

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O80- Encounter for full-term uncomplicated delivery

Interventions

Intervention1: nil: nil Control Intervention1: Entonox gas Vs Oxygen: Entonox(50%Nitrous oxide+50% oxygen) inhalation during labour for 60 secs from beginning of each contraction using a face mask vs

Eligibility

Inclusion criteria

Inclusion criteria: 1.Term pregnancies 37-41 wks POG 2.Singleton pregnancy 3.No maternal or fetal high risk factors.

Exclusion criteria

Exclusion criteria: 1.Multiple pregnancies. 2.Pre-existing chronic illness in mother. 3.Presence of meconium stained liquor 4.Polyhydramnios or oligohydramnios. 5.Macrosomia 6.Maternal contracted pelvis 7.Repeat cesarean section 8.Fetal Heart Rate abnormalities 9.Contraindications of Entonox usage including headinjury, severe asthma 10.Inability or unwillingness of patients to use inhalational gas

Design outcomes

Primary

Measure	Time frame
Intensity of contraction pain by using Wong Baker Faces Pain Rating Scale(numerical score 0â??10)Timepoint: Till relief of labor pain	—

Secondary

Measure	Time frame
1.Maternal side-effects every 10 min by measuring, blood pressure, heart rate (HR), oxyhaemoglobin saturation (SpO2) 2. Low Apgar of neonate- less than 7 in 05 minsTimepoint: Till delivery of patient	—

Countries

India

Contacts

Public ContactIndrani Mukhopadhyay

7 Air Force Hospital

indrani.mukho@gmail.com8861213177

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026