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Injection of Lignocaine versus Dexmedetomidine prior to injection of Etomidate for prevention of myoclonus

A Comparison of pretreatment with Lignocaine versus Dexmedetomidine in prevention of Etomidate induced myoclonus

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/04/024928
Enrollment
60
Registered
2020-04-30
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: Pretreatment with Lignocaine: Injection Lignocaine 1mg /kg in 10 ml normal saline over 10 minutes followed by Injection Etomidate 0.3 mg/kg over 30 seconds Control Intervention1: Pretre

Sponsors

Rohilkhand medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: American society of Anaesthesiologist grade I or II Weight between 45-80 kgs Scheduled for elective surgeries under general anaesthesia

Exclusion criteria

Exclusion criteria: American society of Anaesthesiologist grade III,IV,V Patients refusal for procedure Emergency surgeries History of seizure disorder History of any drug allergies Anticipated difficult airway Known psychiatric disorders Sepsis or systemic infections On pacemakers or Beta blockers Cardiovascular illness and uncontrolled hypertension High intracranial pressure

Design outcomes

Primary

MeasureTime frame
Incidence and severity of Etomidate induced myoclonus within 2 minutes of injectionTimepoint: Incidence and severity of Etomidate induced myoclonus within 2 minutes of injection

Secondary

MeasureTime frame
pulse rate, blood pressure,Spo2Timepoint: Baseline, After drug infusion, Immediately before intubation and 1,3,5 minutes after intubation

Countries

India

Contacts

Public ContactNeeharika Arora

Rohilkhand medical college and hospital

docneehars@gmail.com8077104070

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026