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Role of vitamin B12 in older adults with Depression

Study of Vitamin B12 Supplementation in Late Life Depression

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/04/024920
Enrollment
100
Registered
2020-04-29
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F321- Major depressive disorder, singleepisode, moderate

Interventions

Intervention1: Injection vitamin B12: Eligible participates will be randomised into 2 groups using computer generated tables. Group A will be given Injection vitamin b12 1500mg intramuscular every 3 r

Sponsors

King Georges Medical University Lucknow UP
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: INCLUSION CRITERIA 1. Age >60years 2. Major depressive disorder according to DSM-5(single or recurrent episodes) 3. Willing to give Consent 4. Serum vitamin B12 level â??187-350pg/ml 5. Hindi Mental Status Examination > 24

Exclusion criteria

Exclusion criteria: 1. Not willing to give consent 2. Patient taking MAO inhibitors. 3. History of allergy to escitalopram 4. History of active suicidal ideation and psychotic symptoms 5. History of substance use except tobacco 6. History of stroke or neurodegenerative disorders. 7. Uncooperative for assessment 8. Patients taking Antidepressant in last 15 days at point of entry in study.

Design outcomes

Primary

MeasureTime frame
The primary outcome measures will be assessed on change in severity scale- Hamilton Depression Rating Scale at baselines, 1st week and 4th week. Hindi mental status examination scale will be also used to assess cognition.Timepoint: The primary outcome measures will be assessed on change in severity scale- Hamilton Depression Rating Scale at baseline, 1st week and 4 th week.Hindi mental status examination scale will be also used to assess cognition.—

Secondary

MeasureTime frame
To assess prediction of treatment response after 4 weeks of Antidepressants therapy in late life depression with baseline vitamin B12 and serum homocystiene. 2. To assess prediction of treatment response after 4 weeks of Antidepressants therapy in late life depression with baseline Tumour necrosis factor-Alpha Timepoint: Baseline, 1st week and 4th week.—

Countries

India

Contacts

Public ContactDr Shrikant Srivastava

Department of Geriatric Mental Health

shrikantsrivastava@kgmcindia.edu9621373167

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026