Health Condition 1: C109- Malignant neoplasm of oropharynx,unspecified
Conditions
Interventions
Intervention1: NA: NA
Control Intervention1: NA: NA
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1. All men with histologically confirmed oral and oropharyngeal squamous cell carcinomaand their spouses. 2. Sexually active in the past or present
Exclusion criteria
Exclusion criteria: 1.Previous history of any other malignancy ( including genital cancer ) in the couple. 2.History of hysterectomy in the female partner 3.Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if there is an increased prevalence of genital HPV infection in spouses of men with HPV-associated oral and oropharyngeal cancer as compared to the spouses of men with HPV negative oral and oropharyngeal cancer. Timepoint: 2 years | — |
Secondary
| Measure | Time frame |
|---|---|
| Concordance of HPV positivity with tumour p16 positivity and Hybrid capture 2 done with oral brush sampling. Timepoint: 2 years;To asses if there is a site specific association of the HPV infection among different body sites of the oral cavity and the genital area (cervix and penis) in the husband and wife pair. Timepoint: 2 years;To assess the acceptance of the study intervention by the women in both groups.Timepoint: 2 years | — |
Countries
India
Contacts
Public ContactDr T S Shylasree
Tata Memorial Centre
Outcome results
None listed