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association between P.gingivalis strains in mouth and those in oral cancer and oesophageal cancer tissues

A cross sectional investigation into the possible association between Porphyromonas gingivalis strains isolated from the Oral Microbiome and Oro-Oesophageal Cancer patients by MALDI-TOF MS and AP-PCR

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/04/024835
Enrollment
165
Registered
2020-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C159- Malignant neoplasm of esophagus, unspecified Health Condition 2: C069- Malignant neoplasm of mouth, unspecified

Interventions

Intervention1: SALIVA COLLECTION, SUBGINGIVAL PLAQUE COLLECTION, BIOPSY , P.GINGIVALIS STRAIN TYPING USING MALDI-TOF AND AP-PCR: Arbitrarily primed polymerase chain reaction (AP-PCR) fingerprinting of

Sponsors

INDIAN COUNCIL OF MEDICAL RESEARCH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients suffering from Oral Squamous Cell Carcinoma Patients suffering from Oesophageal Squamous Cell Carcinoma Patients who have not yet undergone any Surgical therapy/ Chemotherapy/ Radiotherapy for treatment of the carcinoma Patients willing to give informed consent Patients with minimum 20 teeth

Exclusion criteria

Exclusion criteria: Patients with any malignancy other than squamous cell carcinoma of the oral cavity/ esophagus Patients undergoing any treatment for carcinoma or its recurrence History of antibiotic use in the previous three months Pregnant or lactating females Patients who received periodontal treatment within the last 6 months Patients who require antibiotic prophylaxis before examination Patients unwilling to participate in the study

Design outcomes

Primary

MeasureTime frame
Arbitrarily primed polymerase chain reaction (AP-PCR) fingerprinting of P. gingivalis isolates from dental plaque, saliva, healthy and tumour tissue in patients with Oral/ Oesophageal cancersTimepoint: baseline—

Secondary

MeasureTime frame
Correlation of P. gingivalis strain with periodontal health statusTimepoint: baseline;Correlation of the prevalence rate of P.gingivalis in saliva with that in dental plaque samples and tumour tissuesTimepoint: baseline;Estimation of prevalence rate of P. gingivalis in healthy and tumour tissue of patients with Oral/ Oesophageal cancers using MALDI-TOF MS.Timepoint: baseline;Estimation of prevalence rate of P. gingivalis in saliva & dental plaque of patients with Oral/ Oesophageal cancers using MALDI-TOF MSTimepoint: baseline;To estimate the prevalence of Periodontal disease in patients suffering from Oral/ Oesophageal cancers by recording the Periodontal status of all subjects Timepoint: BASELINE—

Countries

India

Contacts

Public ContactDR SHIPRA GUPTA

ORAL HEALTH SCIENCES CENTRE, SECTOR 12, PGIMER

teena1472@yahoo.in

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026