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A clinical trial to study the decrease of hypotension associated with the induction dose of propofol

Attenuation of hypotension associated with the induction dose of propofol : A randomized controlled trial comparing vasopressor doses of phenylephrine and mephentermine

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/04/024832
Enrollment
150
Registered
2020-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I00-I99- Diseases of the circulatory system

Interventions

Intervention1: Propofol 2ml (2mg/kg): propofol-saline (PS): 2 ml. 0.9% sodium chloride as control Intervention2: Propofol 2ml (2mg/kg): propofol-phenylephrine (PP): 2 ml (25 mcg/ml) phenylephrine Inte

Sponsors

Department Of Anesthesiology and Critical Care
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective surgery under general anaesthesia. 2.Patients aged 18-60 years. 3.Patients of either sex. 4.Patients coming under American Society of Anesthesiologists physical status I,II(Annexure I).

Exclusion criteria

Exclusion criteria: 1.Patients who are unwilling to participate in the study 2.Patients who are allergic to any of the study drugs 3.Patients scheduled for emergency surgery 4.Patients with history of uncontrolled hypertension and diabetes mellitus 5.Peripheral vascular disease 6.Ischemic heart disease 7.Cardiac arrhythmias 8.Morbid obesity (BMI >35 kg/m2) 9.Pregnant and lactating women 10.Patients with psychiatric abnormalities

Design outcomes

Primary

MeasureTime frame
Heart rate , systolic blood pressure , diastolic blood pressure and mean arterial pressure will be recorded.Timepoint: Heart rate, systolic blood pressure, diastolic blood pressure and mean arterial pressure are Measured at first, second, third, fourth and fifth minute immediately after induction with propofol

Secondary

MeasureTime frame
Number of episodes of hypertension, hypotension, bradycardia and tachycardiaTimepoint: during study period.

Countries

India

Contacts

Public ContactDr Aloka Samantaray

Sri Venkateshwara Institute Of Medical Science

aloksvims@gmail.com9493547653

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026