Comparative study to evaluate the efficacy of Chitosan(natural polymer) with and without synthetic bone material in treatment of periodontal disease(gum disease).

Comparative evaluation of the efficacy of Chitosan gel with and without Nanocrystalline Hydroxyapatite(nHA)and Beta- Tricalcium Phosphate(B-TCP) in the surgical management of Periodontal intrabony defects- A randomized controlled clinical trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/04/024808

Enrollment

Registered

2020-04-22

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: CHITOSAN,NANOCRYSTALLINE HYDROXYAPATITE-BETA-TRICALCIUM PHOSPHATE: Test group- 4% chitosan gel in combination with 60% nanocrystalline hydroxyapatite plus 40% beta- tricalcium phosphate

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients of either sex diagnosed with chronic periodontitis in the age range of 18 to 60. 2. Patients who are systemically healthy. 3. Patient with intra-bony pocket measuring greater than 5mm with evidence of radiographic defect depth of greater than 2 mm. 4. Patients who are willing to comply with the study protocol and will be able to come for regular follow up.

Exclusion criteria

Exclusion criteria: 1. Patients who have undergone periodontal therapy during the previous 6 months, or exhibit poor plaque control after phase I therapy. 2. History of any uncontrolled systemic disease such as diabetes mellitus, hypertension, osteoporosis, unstable or life-threatening conditions, bleeding disorder, undergoing antibiotic, anti-inflammatory or steroid therapy. 3. Current smokers. 4. Pregnant or lactating women. 5. Vegan/ vegetarians. 6. Patients with history of allergy to crustaceans 7. Patients contraindicated for periodontal therapy 8. Tooth with poor prognosis

Design outcomes

Primary

Measure	Time frame
1. Radiographic percentage defect fill 2.Periodontal probing depth 3.Clinical attachment level Timepoint: Baseline,3 months and 6 months	—

Secondary

Measure	Time frame
1.Gingival index 2.Plaque indexTimepoint: Baseline,3 months and 6 months	—

Countries

India

Contacts

Public ContactDr PREETI

K.L.E.SOCIETYS INSTITUTE OF DENTAL SCIENCES, BANGALORE-22

prabhu.ash@gmail.com9845011615

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026