Health Condition 1: M170- Bilateral primary osteoarthritis of knee Health Condition 2: M171- Unilateral primary osteoarthritisof knee
Conditions
Interventions
Intervention1: Diacerein 50 mg OD orally: Dicerein 50 mg OD orally is added to aceclofenac 100 mg BD orally as an add on therapy in patients of knee osteoarthritis in half of the patients
Control Inte
Sponsors
PGIMS Rohtak
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients above 40 years of age. 2. Patients newly diagnosed as having knee osteoarthritis based on clinical diagnosis. 3. Patients having radiographic evidence of OA with a grade of 2 or 3 on Kellgren and Lawrence grading scale. 4. Patients willing to give a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Radiographic grade IV knee osteoarthritis as per Kellgren and Lawrence classification. 2. Patients who have earlier been treated with any disease modifying drug. 3. Patients who have been taking any intra-articular injections for atleast 3 months before the study. 4. History of accompanying osteoarthritis of the hip of sufficient severity to interfere with the functional assessment of the knee. 5. Patients with known hypersensitivity to study drug. 6. History of painful knee condition other than osteoarthritis, gout or post traumatic arthritis. 7. Patients having history of persistent diarrhea or clinically diagnosed peptic ulcer disease. 8. Patients with severe renal insufficency, hepatic disease. 9. Patients having diabetes mellitus. 10. Patients who refused to give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| -VAS Scale -Oxford knee score -Kellgren and Lawrence grading scaleTimepoint: -VAS Scale at 0,4 and 8 weeks -Oxford knee score at 0,4,8 weeks -Kellgren and Lawrence grading scale at 0 and 8 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| KOOS scoringTimepoint: KOOS scoring done at 0, 8 and 12 weeks | — |
Countries
India
Contacts
Public ContactDr Vivek Sharma
PGIMS
Outcome results
None listed