Topical Chloroquine Nasal Drops in Early Stage Covid 19- Impact on Viral load and cure rates

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/04/024729

Enrollment

Registered

2020-04-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: B338- Other specified viral diseases

Interventions

Intervention1: Topical Nasal 0.03% chloroquine eye drops: To receive 0.03% Chloroquine drops 1ml â?? 6 times daily X 10 days. + all treatments & observations recommended by the treatment team Cont

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients testing positive on the RT-PCR Covid-19 test with minimal symptoms and no hypoxemia.

Exclusion criteria

Exclusion criteria: Age b) Pregnancy and lactation c) Known hypersensitivity to chloroquine d) known case of G6PD deficiency, Long QT syndrome and retinopathy

Design outcomes

Primary

Measure	Time frame
1) The Ct values on Day 0, 3, 7, 10 shall be plotted on a graph for all patients. 2) The rate of decline for each patient shall be calculated. The time to cure (Covid 19 RT PCR -ve.) shall be determined 3) The two groups shall be compared for a. Rate of decline of Ct values b. Time to Cure c. Rate of Cure or alternate outcome Timepoint: 1) The Ct values on Day 0, 3, 7, 10 shall be plotted on a graph for all patients. 2) The rate of decline for each patient shall be calculated. The time to cure (Covid 19 RT PCR -ve.) shall be determined 3) The two groups shall be compared for a. Rate of decline of Ct values b. Time to Cure c. Rate of Cure or alternate outcome	—

Measure

Time frame

1) The Ct values on Day 0, 3, 7, 10 shall be plotted on a graph for all patients. 2) The rate of decline for each patient shall be calculated. The time to cure (Covid 19 RT PCR -ve.) shall be determined 3) The two groups shall be compared for a. Rate of decline of Ct values b. Time to Cure c. Rate of Cure or alternate outcome Timepoint: 1) The Ct values on Day 0, 3, 7, 10 shall be plotted on a graph for all patients. 2) The rate of decline for each patient shall be calculated. The time to cure (Covid 19 RT PCR -ve.) shall be determined 3) The two groups shall be compared for a. Rate of decline of Ct values b. Time to Cure c. Rate of Cure or alternate outcome

—

Secondary

Measure	Time frame
Day of CureTimepoint: Day 3,7,10 of admission	—

Countries

India

Contacts

Public ContactAlok Thakar

AIIMS, New Delhi

drathakar@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026