Health Condition 1: C348- Malignant neoplasm of overlappingsites of bronchus and lung
Conditions
Interventions
Intervention1: Intervention Arm: 8 Gy into Two fractions five -7 days apart
Control Intervention1: Standard Arm: 20 Gy in 5 fractions of Radiotherapy once daily
Sponsors
Dr Anil Tibdewal
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age > 18 years and 2.Pathologically proven lung malignancy 3.Patients with clinico â?? radiological diagnosis of MESCC 4.Willing and able to comply with all study requirements, including treatment; able to come for follow-up at regular intervals. 5.Patients able to come for at least first follow up 6.Patients who can provide signed written informed consent
Exclusion criteria
Exclusion criteria: 1.Surgical intervention for treatment of MESCC 2.Previous irradiation over the involved spine segments 3.Patients with symptomatic brain metastases 4.Patients not willing and not able to come for follow up 5.Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the response rate of pain and ambulation (defined as improvement or no deterioration) between the two dose fractionation regimens namely 8 Gy in two fractions (ARM 1) with 20 Gy in 5 fractions (ARM 2) at 4 weeks (-1 week to +2 weeks) in metastatic epidural spinal cord compression of lung cancer patients.Timepoint: 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare response rates at 3 and 6 months To compare duration of response between two arms Incidence of Re-irradiation between two armsTimepoint: 3 and 6 months | — |
Countries
India
Contacts
Public ContactAnil Tibdewal
Tata Memorial Hospital
Outcome results
None listed