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A clinical test to study Hormone(Oxytocin)level and OXTR gene changes in patients with and without persistent pain after surgery to deliver a baby(Caesarean delivery)

Oxytocin hormone levels and OXTR gene polymorphism in patients with and without Chronic Persistent Post Surgical pain following Caesarean delivery-A comparative observational study in tertiary care hospital

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2020/04/024699
Enrollment
50
Registered
2020-04-17
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Department of Anaesthesia University College of Medical Sciences GTB Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients of ASA grade I or II undergoing lower segment caesarean section with Pfannenstiel incision under either spinal or general anaesthesia 2 Patients residing in the vicinity of the hospital

Exclusion criteria

Exclusion criteria: 1 Patients having other causes of chronic pain 2 Patients having chronic neurological disorders 3 Patients having cognitive dysfunction or inability to comprehend various questionnaires

Design outcomes

Primary

MeasureTime frame
Absolute & changes in serum oxytocin levels in patients with and without CPSPTimepoint: At baseline and at the end of 14th week

Secondary

MeasureTime frame
1 Correlation between the Single Nucleotide Polymorphism (SNP) of OXTR gene and risk of CPSP 2 Incidence of CPSP at the end of 14th week 3 The neuropathic component of pain using Pain detect questionnaire (PDQ) 4 Neuropatic Pain Symptom Inventory (NPSI) score 5 Short form-12 (SF-12) questionnaire 6 Sub-group analysis and comparison of various aforementioned parameters will be done between the patients with and without CPSP and SAB and GA group Timepoint: At the end of 1st day, 6th week, 10th week & 14th week

Countries

India

Contacts

Public ContactSpriha Tiwari

University College of Medical Sciences & GTB Hospital

geetanjalidr@yahoo.in9711210772

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026