Changes in Interleukin-35 levels in Gingival crevicular fluid before and after Non-surgical periodontal therapy

Evaluation and comparison of Interleukin-35 levels in Gingival crevicular fluid of Periodontally healthy, Gingivitis and Severe periodontitis patients before and after Non-surgical periodontal therapy: A Clinical controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/04/024656

Enrollment

Registered

2020-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: non surgical periodontal therapy: scaling and root planing as none surgical periodontal therapy once after collection of GCF at baseline. Control Intervention1: NIL: NIL

Eligibility

Inclusion criteria

Inclusion criteria: Group I: Periodontally healthy patients with no clinical attachment loss (CAL), probing pocket depth (PPD) Group II: Gingivitis patients, who show clinical signs of gingival inflammation and also showing no clinical attachment loss, Probing pocket Depth (PPD) 1. Group III: Stage III periodontitis patients who will be identified according to the clinical signs of periodontitis.

Exclusion criteria

Exclusion criteria: 1. Systemic diseases that could affect the periodontium. 2. Tobacco (in any form) and alcoholics. 3. Pregnant or lactating females. 4. Periodontal treatment received in the past 6 months. 5. Use of anti-inflammatory and antibiotic drugs in past 6 months.

Design outcomes

Primary

Measure	Time frame
To evaluate the GCF Interleukin 35 levels in periodontally healthy, gingivitis and severe periodontitis patients after non-surgical periodontal therapy.Timepoint: baseline and 3 months follow up	—

Secondary

Measure	Time frame
To compare GCF Interleukin 35 levels before and after non-surgical periodontal therapy in periodontally healthy, gingivitis and severe periodontitis patients.Timepoint: baseline and 3 months follow up;To compare the GCF Interleukin 35 levels in periodontally healthy sites, gingivitis sites and periodontitis sites in severe periodontitis patients before and after non-surgical periodontal therapy.Timepoint: baseline and 3 months follow up	—

Measure

Time frame

To compare GCF Interleukin 35 levels before and after non-surgical periodontal therapy in periodontally healthy, gingivitis and severe periodontitis patients.Timepoint: baseline and 3 months follow up;To compare the GCF Interleukin 35 levels in periodontally healthy sites, gingivitis sites and periodontitis sites in severe periodontitis patients before and after non-surgical periodontal therapy.Timepoint: baseline and 3 months follow up

—

Countries

India

Contacts

Public ContactDr Surekha Rathod

VSPM DCRC Nagpur

drsurekhar@gmail.com9011071477

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026