Health Condition 1: F20- Schizophrenia
Conditions
Interventions
Intervention1: active intermittent theta burst dtimulation: iTBS will be delivered at 50 Hz at 80-85% of RMT using a figure-of-eight air-film coil. Each session will comprise of 10 pulses having 10 bu
Sponsors
All India Institute of Medical Sciences New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: 1.Male or female right-handed individuals between 18 to 50 years of age meeting the DSM 5 criteria for schizophrenia (American Psychiatric Association, 2013) 2.Illness duration of more than 2 years 3.Patients currently stabilized on same antipsychotics for a period of at least 4 weeks but having significant negative symptoms (SANS scores >=60 and SAPS score 4.Ability to read Hindi or English language 5.Patients with capacity and willingness to give informed consent
Exclusion criteria
Exclusion criteria: 1-Presence of any other psychiatric disorder or substance use disorder (except caffeine or nicotine) through M.I.N.I 7.0. screening. 2-History of seizure. 3-History of receiving any treatment with brain stimulation. 4- Known or suspected pregnancy or currently lactating. 5-Presence of unstable medical illness. 6-History suggestive of space occupying brain lesion or cerebro-vascular accident. 7-Having implanted device or metal in brain/head or cardiac pacemaker or ferromagnetic dental braces.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Change in fNIRSTimepoint: Baseline assessment will be done within a week prior to initiating rTMS. Assessment will be repeated within 24 hours at the end of last session. | — |
Primary
| Measure | Time frame |
|---|---|
| Change in SANS scoresTimepoint: Baseline assessment will be done within a week prior to initiating rTMS. Assessment will be repeated within 24 hours at end of 5th session, and the last session. | — |
Countries
India
Contacts
Public ContactDr Rohit Verma
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed