FindTrial
Sign In

To evaluate different forms of liposomal Amphotericin B namely sonicated gel, unsonicated drop and sonicated drop for the treatment of fungal keratitis

Comparative evaluation of different formulations namely sonicated gel form, unsonicated drop and sonicated drop of Liposomal Amphotericin B for the treatment of fungal keratitis

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/04/024550
Enrollment
45
Registered
2020-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H160- Corneal ulcer

Interventions

Intervention1: LIPOSOMAL AMOHOTERICIN B: 15 PATIENTS TREATED WITH SONICATED GEL FORM OF LIPOSOMAL AMPHOTERICIN B , 15 PATIENTS TREATED WITH UNSONICATED DROP FORM OF LIPOSOMAL AMPHOTERICIN B, 15 PATIEN

Sponsors

Ocular pharmacology aiims
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ADULTS PATIENT MORE THAN OR EQUAL TO 18 YEARS KOH SMEAR POSITIVE FOR FUNGAL KERATITIS PATIENTS WILLING TO GIVE INFORMED CONSENT PATIENTS WILLING TO FOLLOW UP FUNGAL HYPHAE POSITIVE ON CONFOCAL MICROSCOPY

Exclusion criteria

Exclusion criteria: IMPENDING PERFORATION, CORNEAL PERFORATION EVIDENCE OF BACTERIA ON GRAM STAIN AT THE TIME OF ENROLLMENT BILATERAL ULCER ALLERGIC TO STUDY MEDICATIONS NO LIGHT PERCEPTION IN THE AFFECTED EYE PREGNANT OR LACTATING FEMALE

Design outcomes

Primary

MeasureTime frame
TIME TO RESOLUTION OF EPITHELIAL DEFECT TIME TO RESOLUTION OF CORNEAL INFILTRATES TIME TO RESOLUTION OF HYPOPYONTimepoint: 3 MONTH—

Secondary

MeasureTime frame
CORNEAL OPACITY AT THE END OF 3 MONTHS AFTER ENROLLMENT CORNEAL VASCULARISATION AT THE END OF 3 MONT AFTER ENROLLMENT BEST CORRECTED VISUAL ACQUITY AT THE END OF 3 MONT AFTER ENROLLMENTTimepoint: 3 MONTH—

Countries

India

Contacts

Public ContactDr Vishal kumar

DR R.P CENTRE FOR OPHTHALMIC SCIENCE

radhika_tan@yahoo.com01126593145

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 10, 2026