Health Condition 1: L608- Other nail disorders
Conditions
Interventions
Intervention1: oral itraconazole pulse therapy: The cases were given oral itraconazole 400 mg daily for the first week only of each month, for 3 months, followed by a drug-free follow-up period of 9 m
Sponsors
Dr Prasenjeet Mohanty
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients having one or more toenail and/or fingernail fungal infections of the following types: distal subungual onychomycosis, proximal subungual onychomycosis, superficial white/black onychomycosis, endonyx onychomycosis, total dystrophic type onychomycosis or mixed onychomycosis. 2. Patients with diabetes mellitus, immunocompromised patients, and organ transplant patients will be included, although we consider that these patient groups success rates could be considerably less.
Exclusion criteria
Exclusion criteria: 1. Patients who used systemic antifungal or isotretinoin within 6months. 2. Permanent or semi-permanent discoloration of the nail plate (e.g. topical therapeutics, cosmetics or professional dye exposure) as they can cause various physiological changes to the nail plate in addition to discoloration. 3. Subungual hematoma, nevoid subungual formation, bacterial nail infections, and concomitant nail disorders such as psoriasis of nail plate, lichen planus and atopic dermatitis. 4. Fungal infections of other body parts. 5. Any generalized skin disease. 6. Pregnancy. 7. Patients having liver or renal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| % of patients with excellent outcomeTimepoint: December 2019 to December 2020 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Species detection 2. % of incomplete cure and relapse. 3. Safety profile of interventionTimepoint: December 2019 to December 2020 | — |
Countries
India
Contacts
Public ContactSiddhartha Dash
S.C.B. Medical College and Hospital
Outcome results
None listed