Health Condition 1: I501- Left ventricular failure, unspecified Health Condition 2: I30-I52- Other forms of heart disease
Conditions
Interventions
Control Intervention1: NIL: NIL
Control Intervention2: NIL: NIL
Sponsors
Kasturba Medical College Manipal Academy of Higher Education Manipal
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age greater than 18 years 2. Able to provide written and informed consent 3. Left ventricular ejection fraction less than 40% 4. NYHA II- IV symptoms 5. Newly diagnosed heart failure with reduced ejection fraction 6. Chronic heart failure with reduced ejection fraction patients who are on optimal medical treatment but not started on ARNI Sacubutril- Valsartan
Exclusion criteria
Exclusion criteria: 1. Recent coronary revascularization within 3 months 2. Hypotension 3. Renal dysfunction 4. Valvular heart disease other than mitral regurgitation 5. Recent cardiac resynchronization therapy device implantation within 3 months 6. Any contraindication for ARNI Sacubutril -Valsartan
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diastolic strain rate at the baseline and at 3 months after starting Sacubutril - Valsartan will be compared and will also be compared with the control groupTimepoint: 1. At baseline before starting Sacubutril- Valsartan 2. At 3 months after starting the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Global longitudinal strain, E/E, LV Ejection fraction at baseline before starting the drug and after starting the drug , will be compared and will also be compared with the control groupTimepoint: 1. At baseline before starting Sacubutril- Valsartan 2. At 3 months after starting the treatment | — |
Countries
India
Contacts
Public ContactDr Monika Jawanjal
Kasturba Medical College, Manipal Academy of Higher Education, Manipal
Outcome results
None listed