Health Condition 1: R00-R09- Symptoms and signs involving the circulatory and respiratory systems
Conditions
Interventions
Intervention1: Inhalational isoflurane via the AnaConDa™: After connecting the patients the ICU ventilators, and starting an intravenous Fentanyl infusion (0.5-15 microgram/kg/min) for analgesia, pati
Sponsors
Dept of Anaesthesia Critical Care and Pain Tata Memorial Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age 50-80 years 2. Weight 50-120 kg 3. Elective post-operative patients anticipated to require sedation between 12 -24 for elective mechanical ventilation. 4. Hemodynamically stable patients (not requiring more than 0.3 microgram/kg/min of noradrenaline) 5. Patients willing to participate in the trial by giving written informed consent.
Exclusion criteria
Exclusion criteria: 1. Contraindications to use of HME filter during mechanical ventilation, these may include, but not limited to: excessive secretions or pulmonary hemorrhage likely to block the filter, indications for reducing apparatus dead space. 2. Head trauma and neurosurgical patients or mental obtundation due to any other reason preoperatively. 3. Patients with raised ICP. 4. Low GCS ( 5. Pregnant or breast feeding women. 6. Family or personal history of malignant hyperthermia. 7. Patients already receiving sedation for more than >6 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of time spent between Richmond Agitation Sedation Scale scores of either -3 or -4.Timepoint: Any time till the patient is planned for extubation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Incidence of post-operative delirium as measured by Confusion Assessment Method(CAM-ICU)Timepoint: At any point during the course of sedation if the RASS score is not between -3 or -4;2. Ease of administration (incidence of and proportion of difficulties in managing the equipment for administration overall and per patient)Timepoint: At the time when the patient is planned for extubation or at the end of 24 hours;3. Incidence of renal, hepatic, hemodynamic and other adverse effects and others, if anyTimepoint: Any time till discharge | — |
Countries
India
Contacts
Public ContactDr Atul Kulkarni
Tata Memorial Centre
Outcome results
None listed