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Pain Control after Root Canal Treatment

Efficacy of Proteolytic Enzymes on Postendodontic Pain after Single-Visit Root Canal Treatment of Teeth with Symptomatic Irreversible Pulpitis: A Prospective, Single-Blind Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/04/024434
Enrollment
75
Registered
2020-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Serratiopeptidase: Serratiopeptidase is a proteolytic enzyme produced by purification from culture of Serratia E-15 bacteria. Patients will be administered 10mg Serratiopeptidase orally

Sponsors

Pratyasha Kaushik
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients between 18 years and 60 years of age. Patients presenting with pain associated with irreversible pulpitis in mandibular molars with no clinical or radiographic signs or symptoms of acute or chronic apical periodontitis. No history of taking analgesics in the previous 12 hours prior to presenting for treatment. Patients presenting with American Society of Anesthesiologists I or II medical history. Patients providing informed consent. Patients who can read and understand the pain scoring criteria.

Exclusion criteria

Exclusion criteria: Presence of any systemic disorder or sensitivity or allergy that prevents the use of serratiopeptidase and trypsin-chymotrypsin. Patients having hepatic and renal disorders. Patients having gluten allergy. Presence of periapical radiolucency and swelling or any other condition that prevents single-visit root canal treatment. Patients having teeth not suitable for restoration, or having serious periodontal disease that render the teeth unsuitable for endodontic treatment. Pregnant or lactating patients. Teeth will be excluded if there is any overestimation of the working length, inadvertent overinstrumentation through the apical foramen, or extension of the root filling material beyond the working length.

Design outcomes

Primary

MeasureTime frame
Serratiopeptidase and Trypsin:chymotrypsin may prove to be an effective anti-inflammatory and analgesic agent for post-endodontic pain following single visit root canal treatmentTimepoint: 6 hours, 12 hours, 24 hours, 48 hours and 72 hours.—

Secondary

MeasureTime frame
Serratiopeptidase and Trypsin:chymotrypsin may prove to be more effective than placebo for post-endodontic pain following single visit root canal treatmentTimepoint: 72 hours—

Countries

India

Contacts

Public ContactDr Mamta Kaushik

Army College of Dental Sciences

mamkaushik@gmail.com9391010325

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026