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Vitamin D dose response on bone resorption rates and calcium absorption in vitamin D deficient and sufficient states

Stable Isotope studies to understand Vitamin D dose response on Bone Resorption rates and fractional Calcium absorption in Vitamin D deficient and sufficient states.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024395
Enrollment
120
Registered
2020-03-31
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Vitamin D tablets: Vitamin D tablets of varying doses (200 IU/d, 400 IU/d, 600 IU/d, 800 IU/d) in each subgroup will be provided for 12 week intervention period In vitamin D sufficient

Sponsors

Department of Biotechnology Government of India
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Non pregnant non lactating women Female volunteers Age 35 years 25-OHD deficient 30 ng/mL

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Age >18 and Any disease or chronic illness Recent history (3 months prior) of serious infection, injuries and/or surgeries Any food allergy or food intolerance

Design outcomes

Primary

MeasureTime frame
Optimization of dose levels for Vit D supplementation and plasma Vit D levels, using changes in bone resorption rateTimepoint: 3:Baseline,Midpoint,Endline—

Secondary

MeasureTime frame
The study would help in establishing bone resorption rate and the derived BMB that is directly linked with bone health, as a new marker for Vit D supplementation efficacy studies. Ca bio-availability measurements in Vit D deficient and sufficient states. This is important for defining Vit D and Calcium supplementation needed Timepoint: 3:Baseline,Midpoint,Endline—

Countries

India

Contacts

Public ContactDr Prashanth Thankachan

St Johns Research Institute

praxmail@gmail.com9886006166

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026