To study postoperative pain relief after instillation of ;local anaesthetic ropivacaine and addition of steroid dexamethasone to it in patients after kidney stone removal.

Intermittent peri-tubal instillation of dexamethasone and ropivacaine on postoperative analgesia after percutaneous nephrolithotomy : A Prospective Randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/024332

Enrollment

Registered

2020-03-30

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N200- Calculus of kidney

Interventions

Intervention1: The patients will be divided into two groups by computer generated randomization and sealed envelope technique: Group RD: Receiving a combination of 0.2% ropivacaine (20 ml) with dexame

Eligibility

Inclusion criteria

Inclusion criteria: All ASA I and II adult patients aged 18-60 years with a diagnosis of nephrolithiasis (Staghorn, Pelvic or Pelvic-Calyceal) and requiring placement of nephrostomy tube post-operatively.

Exclusion criteria

Exclusion criteria: EXCLUSION CRITERIA Age more than 60 years Obesity (body mass index more than 30) Chronic analgesic use Prior percutaneous nephrolithotomy done Requirement of multiple access tracts during the surgery. History of diabetes mellitus

Design outcomes

Primary

Measure	Time frame
To compare the duration of analgesia between ropivacaine and ropivacaine-dexamethasone group during intermittent instillation for surgical site pain along the nephrostomy tube in postoperative period in patients undergoing percutaneous nephrolithotomy.Timepoint: O hrs, 2 hrs, 4 hrs, 8 hrs, 16 hrs, 32 hrs and 48 hours postoperatively	—

Secondary

Measure	Time frame
To assess dexamethasone related complications like wound infection and delayed healingTimepoint: 7 days postoperatively.;To assess the effects of intervention on levels of systemic inflammatory markers (ESR and CRP).Timepoint: 0,1,2 days postoperatively;To compare the effect of dexamethasone on block characteristics which includes onset and peak effect of blockade and efficacy in terms of maximum numeric rating scale (NRS)Timepoint: 2,4,6,12,24, 48 and 60 hours postoperatively;To determine the total cumulative dose of local anesthetic and dexamethasone required and the total cumulative dose of IV rescue analgesic (Fentanyl) in both the groups.Timepoint: 2,4,6,12,24, 48 and 60 hours postoperatively	—

Measure

Time frame

To assess dexamethasone related complications like wound infection and delayed healingTimepoint: 7 days postoperatively.;To assess the effects of intervention on levels of systemic inflammatory markers (ESR and CRP).Timepoint: 0,1,2 days postoperatively;To compare the effect of dexamethasone on block characteristics which includes onset and peak effect of blockade and efficacy in terms of maximum numeric rating scale (NRS)Timepoint: 2,4,6,12,24, 48 and 60 hours postoperatively;To determine the total cumulative dose of local anesthetic and dexamethasone required and the total cumulative dose of IV rescue analgesic (Fentanyl) in both the groups.Timepoint: 2,4,6,12,24, 48 and 60 hours postoperatively

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Countries

India

Contacts

Public ContactAnkur Luthra

PGIMER, Chandigarh

zazzydude979@gmail.com09868057732

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 12, 2026