Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: FiO2 0.8: Intraoperative use of fractional oxygen of 0.8 during general anaesthesia with controlled ventilation
Control Intervention1: FiO2 0.3: Intraoperative use of fractional oxygen
Sponsors
Dr Souvik Maitra
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients (aged between 18 and 60y) of either sex and American Society of Anesthesiologists Physical Status I or II, undergoing any surgery of more than 2h duration under general anaesthesia with endotracheal intubation will be recruited in this study.
Exclusion criteria
Exclusion criteria: 1. Patientsâ?? refusal 2. Pregnancy 3. Patients undergoing emergency surgery. 4. Patients with any pre-existing lung diseases 5. Patients with any pre-existing neurological diseases 6. Patients with peripheral vascular diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentages of decline in dominant side internal carotid artery peak blood flow velocity measured by spectral Doppler with a FiO2 of 0.8 in comparison to FiO2 0.3.Timepoint: 90 minutes after induction of anaesthesia | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentages of decline in non- dominant side internal carotid artery peak blood flow velocity measured by spectral Doppler with a FiO2 of 0.8 in comparison to FiO2 0.3. 2. Percentages of decline in both dominant and non-dominant side vertebral artery peak blood flow velocity measured by spectral Doppler with a FiO2 of 0.8 in comparison to FiO2 0.3. 3. Change in the internal carotid and vertebral artery resistive index in both the groups. Timepoint: 90 minutes after induction of anaesthesia. | — |
Countries
India
Contacts
Public ContactSouvik Maitra
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed