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Comparing effects of Sevoflurane and Desflurane (inhalational anesthetics) in elderly patients undergoing Neurosurgery

COMPARISON OF RECOVERY CHARACTERISTICS BETWEEN DESFLURANE AND SEVOFLURANE ANAESTHESIA IN ELDERLY PATIENTS UNDERGOING ELECTIVE SUPRATENTORIAL CRANIOTOMY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024294
Enrollment
78
Registered
2020-03-26
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z00-Z99- Factors influencing health status and contact with health services

Interventions

Intervention1: Desflurane Anaesthesia: Desflurane is used to maintain anaesthesia Control Intervention1: Sevoflurane: Sevoflurane is used to maintain anaesthesia

Sponsors

MS Ramaiah Medical College
Lead Sponsor
Dr M Naga Sailaja
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Age greater than 65 years ASA physical status 1, 2, 3 Patients undergoing elective supratentorial craniotomies Procedures lasting a minimum of 2 hours

Exclusion criteria

Exclusion criteria: Patients with GCS Patients with BMI > 30 Patients with CT evidence of increased intra cranial pressure Intracranial aneurysm or Arteriovenous malformations Patients with history of psychiatric illness and/or receiving neuropsychiatric drugs Patients with history of alcohol or substance abuse Patients undergoing re do procedures

Design outcomes

Primary

MeasureTime frame
To assess the recovery in terms of emergence time, extubation time and recovery time after sevoflurane and desflurane anaesthesia in elderly patients undergoing elective supratentorial craniotomy.Timepoint: Emergence time: time taken to open eyes after cutting off inhalational agent, extubation time: time taken for extubation after cuttimg off agent, recovery time: time taken for patient to say his or her name will be measured. Immediate post operative period and one hour post operatively—

Secondary

MeasureTime frame
To study intraoperative haemodynamic variables between the two groupsTimepoint: Intraoperative Heart rate (HR), Systolic Blood pressure(SBP), Diastolic blood pressure (DBP), Mean Arterial Pressure (MAP) will be recorded at baseline (before induction), immediately after induction, immediately after intubation, after achieving MAC of 1.0 with either of agents, at the time of pin application and thereafter every 15mins till the inhalation agents are tapered at the end of surgery;To compare the cognitive function postoperatively using Short Orientation Memory Concentration Test (SOMCT).Timepoint: One hour after shifting to ICU and will be compared between the two groups;To compare the intra operative brain conditionTimepoint: After dural opening—

Countries

India

Contacts

Public ContactDr Geetha L

M.S. Ramaiah Medical College

geetha4kiran@yahoo.in9611897899

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026