Health Condition 1: J86- Pyothorax
Conditions
Interventions
Intervention1: Intrapleural Streptokinase group: In the intrapleural streptokinase group (i.e. group A1 and B1)three additional doses of Intrapleural Streptokinase would be administered daily over thr
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: Children less than 18 years age with empyema. Empyema will be defined as â??presence of pus on a diagnostic pleural tap in children with clinical and/or radiological features consistent with pneumonia and parapneumonic pleural effusionâ??.
Exclusion criteria
Exclusion criteria: 1.Prior chest tube drainage with use of intrapleural fibrinolytics or any surgical intervention 2.Contra-indications to fibrinolytic therapy viz (a)Known Coagulopathy or Bleeding disorders or (b)Confirmed Pneumothorax or bronchopleural fistula (c)Head trauma during the preceding 2 weeks
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary objective To compare the efficacy of three doses versus more than three doses of intrapleural streptokinase in management of empyema in children. Timepoint: At discharge | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the safety, markers of pulmonary function and radiological features in three doses versus more than three doses of intrapleural streptokinase in management of empyema in children.Timepoint: Three months after discharge | — |
Countries
India
Contacts
Public ContactKamal Kumar Singhal
PGIMER, Chandigarh.
Outcome results
None listed