COMPARISON BETWEEN KETOPROFEN AND KETOPROFEN WITH DOXYCYCLINE GEL AS LOCAL DRUG DELIVERY IN SMOKERS AND NON SMOKERS CHRONIC PERIODONTITIS PATIENTS.

Comparative evaluation of ketoprofen gel alone and in combination with doxycycline gel as local drug delivery in the treatment of chronic periodontitis among smokers and non-smokers.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/024280

Enrollment

Registered

2020-03-26

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis Health Condition 2: F172- Nicotine dependence

Interventions

Intervention1: administration of 2.5% ketoprofen gel alone as local drug delivery in periodontal pockets.: 2.5% ketoprofen gel will be administered as local drug delivery in periodontal pockets in smo

Eligibility

Inclusion criteria

Inclusion criteria: (1) at least 20 natural teeth present (2) probing depth of at least 4mm and clinical attachment loss of at least 2mm in all quadrants of the mouth. (3) smokers group having subjects smoking at least 10 cigarettes/bidis per day (4) non smokers group having subjects who have never smoked cigarettes or any other form of tobacco. (5) willingness to comply with the study protocol.

Exclusion criteria

Exclusion criteria: (1) existing systemic disease that may affect the severity or progression of periodontal disease. (2) medication consumption that may influence the periodontium (e.g. non steroidal anti-inflammatory drugs or antibiotics) within 6 months preceding the beginning of intervention. (3)subjects undergoing orthodontic treatment or extensive restorations (4) patients with aggressive periodontitis or multiple caries (5) patients during pregnancy or lactation (6) patients allergic to doxycycline or ketoprofen

Design outcomes

Primary

Measure	Time frame
reduction in gingival inflammation, probing depth and clinical attachment lossTimepoint: one month and three months.	—

Secondary

Measure	Time frame
n/aTimepoint: n/a	—

Countries

India

Contacts

Public ContactDr Krupali Gandhi

Manubhai Patel Dental College and oral research institute

priya_darshinikud@rediffmail.com7567796090

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026