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This is a study taken to see the effects of tab tizanidine which is a sedative on propofol consumption during general anaesthesia.

A PROSPECTIVE RANDOMISED CONTROL STUDY TO ASSESS THE EFFECT OF ORAL TIZANIDINE AS PREMEDICATION ON PROPOFOL REQUIREMENT FOR INDUCTION IN ENTROPY GUIDED GENERAL ANAESTHESIA

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024250
Enrollment
60
Registered
2020-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K55-K64- Other diseases of intestines

Interventions

Intervention1: Tab tizanidine 4 mg: Premedication with tab tizanidine 4mg with a sip of water 90 mins prior to surgery Control Intervention1: Sugar pellets: Premedication with sugar pellet 90 mins pri

Sponsors

Bangalore medical College and research institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patient who are willing to give informed consent. 2) Patients of age 18-60 years of either sex. 3) ASA grade I and II. 4) Patients scheduled for elective surgery lasting for 90-120 mins under general anaesthesia

Exclusion criteria

Exclusion criteria: 1.Patients who are not willing to give informed consent 2.SA grade III and above. 3.Age 60 years. 4.Patients with hemodynamic instability. 5.Presence of systemic disorders involving respiratory, cardiac, renal or hepatic system 6.Patients with anticipated difficult airway. 7.Pregnant women.

Design outcomes

Primary

MeasureTime frame
Dose of propofol required for induction under entropy guidanceTimepoint: Till entropy reads 40-60 following induction

Secondary

MeasureTime frame
Hemodynamic stress response to laryngoscopy and intubationTimepoint: Till 10 mins post intubation

Countries

India

Contacts

Public ContactDr Sudha Shree P

Bangalore medical College and research institute

sumithramelur@gmail.com9448171403

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026