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To find out effect of Injection Zoledronic acid for treatment of bone weakening condition in patients having long term liver problems/damage.

Efficacy and safety of zoledronic acid as add on therapy to calcitriol in patients of osteoporosis with liver cirrhosis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024247
Enrollment
60
Registered
2020-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K746- Other and unspecified cirrhosis ofliver

Interventions

Intervention1: Inj. Zoledronic Acid: Test Group- Tab. Calium 1000mg/day+ Tab Calcitriol 0.25micro gram twice daily + Injection Zoledronic acid 5 mg once a year. Control Intervention1: Tab Calcium

Sponsors

Pt BD Sharma PGIMS Rohtak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Either gender adult patients with Osteoporosis with liver cirrhosis

Exclusion criteria

Exclusion criteria: Hyperparathyroidism Acute Kidney Injury Diabetes, Chronic kidney disease Patients on corticosteroids, antiepileptics, antitubercular drugs Hyperparathyroidism, malabsorption disorders Thyroid disorders Hepatocellular carcinoma/ any other malignancy Postmenopausal, pregnant/lactating females

Design outcomes

Primary

MeasureTime frame
1. Changes in Bone mineral Density 2. Fracture risk assessment score (FRAX Score)Timepoint: 1 year—

Secondary

MeasureTime frame
1. Incidence of pathological fracture 2. Effect on quality of life using IOF Quellafo 41, EQ 5D-3L, EQ VAS questionnaires 3. Changes in biochemical parameters- Vitamin D levels, ALP, 24hours urone calcium levels. Timepoint: 1. 1 year 2. 1 years 3. 3,6,9,12 months.—

Countries

India

Contacts

Public ContactDr Deepak Nehra

Pt BD Sharma PGIMS Rohtak

deepaknehra30@gmail.com8901351943

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026