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A comparison of Desflurane and propofol in terms of inflammatory potential and impact on respiratory sytem in obese patients undergoing laparoscopic bariatric surgeries

Desflurane versus total intravenous anaesthesia with propofol: Effects on inflammatory biomarkers and respiratory mechanics in laparoscopic bariatric surgery- A prospective randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024154
Enrollment
60
Registered
2020-03-23
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E669- Obesity, unspecified

Interventions

Intervention1: Desflurane: General Anaesthesia maintained with inhalational agent Desflurane Control Intervention1: Propofol: General Anaesthesia maintained with total intravenous anaesthesia with pro

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. BMI >30 kg/m2 2. ASA Status II 3. Patients scheduled for elective laparoscopic bariatric surgery

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. ASA III, IV 3. Known allergy to propofol 4. Impaired cardiopulmonary, hepatic, renal function 5. History of chronic inflammation or treatment with immunosuppressants 6. Malignancy 7. Active smoking 8. Obstructive or restrictive lung disease 9. Alcohol dependent currently 10. Pre-existing coagulation disorders 11. Active or resolving pulmonary or systemic infection

Design outcomes

Primary

MeasureTime frame
To compare plasma concentration of interleukin (IL)-6 in patients anaesthetised with propofol and desfluraneTimepoint: prior to induction of anaesthesia (baseline), just after induction (T1) just before extubation (T3)—

Secondary

MeasureTime frame
Measurement of Airway resistance using impulse oscillometry in both groupsTimepoint: pre-operatively (On admission) post-operatively (24 hours after surgery);Respiratory parameters [Tidal volume, respiratory rate, Peak and plateau pressures, driving pressure, compliance, SpO2, PaO2/FiO2 (oxygenation)] in both groupsTimepoint: just after induction (T1) 30 mins after pneumoperitoneum (T2) just before extubation (T3)—

Countries

India

Contacts

Public ContactSukriti Jha

All India Institute of Medical Sciences, New Delhi

lokeshkashyap@yahoo.com9873531192

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026