Effect of nasal administration of brahmi ghritha on cognitive functions and mode of action of nasal medication with Brahmi ghritha

A clinical study to evaluate the efficacy of Brahmi ghritha nasya on cognitive functions and its bioavailability

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/024148

Enrollment

Registered

2020-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nasya (Nasal medication): Brahmi ghritha Nasya 8 bindhu for 7 days Control Intervention1: Not applicable: Not applicable

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy male volunteers between 20-40 age group with BMI 18.5 â?? 24.9 2. Nasya Arha as per ayurveda texts 3. Healthy volunteers as determined by screening assessments and Principle investigatorâ??s judgement

Exclusion criteria

Exclusion criteria: 1. Known case of Hypersensitivity to nasal medications 2. Persons under regular and frequent medication for any physical or mental illness 3. History of alcoholism, tobacco intake since 6 months 4. Clinically relevant history of disease related to respiratory, gastro intestinal, cardiovascular, neurological, renal, hepatic and hematological systems

Design outcomes

Primary

Measure	Time frame
1. Assessment of cognitive function with Addenbrookes Cognitive Examination - ACE-III Indian English and on 0th day and 7th day of brahmi ghritha nasya 2. Identification of bacoside A in blood plasma after nasya karma using HPLC method on 7th day of therapy Timepoint: 1. Assessment of cognitive function with Addenbrookes Cognitive Examination - ACE-III Indian English and on 0th day and 7th day of brahmi ghritha nasya 2. Identification of bacoside A in blood plasma after nasya karma using HPLC method on 7th day of therapy	—

Measure

Time frame

1. Assessment of cognitive function with Addenbrookes Cognitive Examination - ACE-III Indian English and on 0th day and 7th day of brahmi ghritha nasya 2. Identification of bacoside A in blood plasma after nasya karma using HPLC method on 7th day of therapy Timepoint: 1. Assessment of cognitive function with Addenbrookes Cognitive Examination - ACE-III Indian English and on 0th day and 7th day of brahmi ghritha nasya 2. Identification of bacoside A in blood plasma after nasya karma using HPLC method on 7th day of therapy

—

Secondary

Measure	Time frame
Not applicableTimepoint: Not applicable	—

Countries

India

Contacts

Public ContactDr Prathibha C K

Amrita School of Ayurveda Amritapuri Amrita Vishwa Vidyapeetham India

drprathibhack@gmail.com9495637695

Outcome results