“The Study to Evaluate Efficacy of Dexamethasone(Steroid) Injection on Post-Operative Sequelae like Pain,swelling,reduced mouth opening and quality of life after Lower Wisdom Tooth Removal. ?

“A Randomised Clinical Trial to Evaluate Efficacy of Dexamethasone Injection in Pterygomandibular Space or Submandibular Space on Post-Operative Sequelae after Mandibular Third Molar Surgical Extraction. ?

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2020/03/024130

Enrollment

Registered

2020-03-20

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Intervention-Dexamethasone injection(8mg in 2ml) : Dexamethsone injection in Pterygomandibular space vs Dexamethsone injection in Submandibular space Control Intervention1: Dexamethaso

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient with an impacted mandibular third molar LEVEL-B(Pell &Gregory Classification) and indicated for its surgical extraction. 2. Patient who willingly gives consent for the being involved in the study 3. Healthy adult patients in the age group of 18-45 years. 4. Patient is able to understand & carry out instructions given by investigators.

Exclusion criteria

Exclusion criteria: 1. Patient known to be allergic to Local Anaesthesia and other drugs used in the study. 2. Patients with a known allergy to co-amoxiclav group or NSAID drugs. 3. Patients with any underlying systemic condition/medication which will interfere with drug metabolism. 4. Patients on immunosuppresants. 5. Existence of acute infection and or pain & swelling at the time of surgery 6. Inability to follow the instructions or co-operation during study & drop outs or attrition during study. 7. Pregnant females and Lactating mothers.

Design outcomes

Primary

Measure	Time frame
Reduction of Pain ,Swelling,Trismus.Timepoint: Assessment will be done on operative day,Postoperative 24hrs(Day1),48hrs(Day2),168hrs(Day7) 1.Pain will be evaluated by Visual Analog Scale. Use of analgesic will be recorded. 2.Facial swelling will be evaluated by measuring distance between six predetermined points.The points will be canthus to gonion, corner of the mouth to tragus of the ear and tragus to pogonion. 3.Maximum mouth opening will be evaluated by interincisal distance.	—

Measure

Time frame

Reduction of Pain ,Swelling,Trismus.Timepoint: Assessment will be done on operative day,Postoperative 24hrs(Day1),48hrs(Day2),168hrs(Day7) 1.Pain will be evaluated by Visual Analog Scale. Use of analgesic will be recorded. 2.Facial swelling will be evaluated by measuring distance between six predetermined points.The points will be canthus to gonion, corner of the mouth to tragus of the ear and tragus to pogonion. 3.Maximum mouth opening will be evaluated by interincisal distance.

—

Secondary

Measure	Time frame
Quality of life after third molar extractionTimepoint: Assessment will be done daily upto 7 days using Quality of Life (OHQOLUK-16 SCALE) Refrence article-Mc Grath C, Comfort MB, Lo EC, Luo Y (2003) Changes in quality following third molar surgery-the immediate postoperative period. Br Dent J 194(5):265–268	—

Countries

India

Contacts

Public ContactShubham Pradip Palve

NAIR HOSPITAL DENTAL COLLEGE

tgandhewar@yahoo.com9819323729

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026