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A clinical trial to compare two different treatment modalities for treating nausea and/or vomiting in the emergency

A Randomised controlled trial on inhaled Isopropyl alcohol versus orally disintegrating Ondansetron in the treatment of nausea and/or vomiting in Emergency Department

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024122
Enrollment
90
Registered
2020-03-20
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K929- Disease of digestive system, unspecified

Interventions

Intervention1: Inhaled isopropyl alcohol: A pre-treatment assessment will be made on a scale on 0-10 on a Verbal Numeric Response Scale (VNRS), where a score of 0 indicates no nausea or vomiting and a

Sponsors

Mohanapriya V S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All patients who are hemodynamically stable, aged 18 and above, with complaints of nausea and/or vomiting, with severity of 3 or more in Verbal Numeric Response Scale (VNRS).

Exclusion criteria

Exclusion criteria: Patient not willing to participate in the study Age less than 18 years Pregnant patients Patients using antiemetic prior to presentation Inability to inhale through nares Allergic to inhaled isopropyl alcohol or ondansetron Administration of drugs contraindicating alcohol administration Patients with history of intestinal obstruction, carcinoma or hemoptysis Patients with hemodynamic instability Patients with smell of alcohol in their breath

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study is to assess the mean nausea and/or vomiting reduction measured from 0 to 10 by VNRS scale.Timepoint: 10,20 and 30 minutes and at end of 2 hours

Secondary

MeasureTime frame
The secondary outcome includes the need for rescue antiemetic therapy and adverse effects during the studyTimepoint: 10, 20 and 30 minutes and at end of 2 hours

Countries

India

Contacts

Public ContactMohanapriya V S

Sundaram Medical Foundation

mogu.somu@yahoo.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026