Health Condition 1: B999- Unspecified infectious disease
Conditions
Interventions
Intervention1: Nil: Nil
Control Intervention1: Nil: Nil
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: consecutive sepsis patients admitted to ICU, of 18-60 year age group and staying in ICU for at least 10 days
Exclusion criteria
Exclusion criteria: patients with pre-existing history of liver cirrhosis, splenomegaly, aplastic anemia, idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, heparin-induced thrombocytopenia, pregnancy, HIV infection, systemic lupus erythematosus, vasculitis, prosthetic cardiac valve replacement, malignancy, chemotherapy in last 30 days, and any radiation therapy in last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the 30-day mortality among sepsis patients with thrombocytopenia verses those without thrombocytopenia at ICU admissionTimepoint: ICU admission(Day 1) to 30 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital length of stayTimepoint: Duration of hospital stay;maximal dose and duration of vasopressor use, need of renal replacement therapy, lowest Pao2/FiO2 ratio, major bleeding episodes and total blood products used, ICU length of stay, mechanical ventilation days, number of patients requiring mechanical ventilationTimepoint: Duration of ICU stay;To analyse the risk factors for onset of thrombocytopenia in sepsis patients on ICU admissionTimepoint: ICU admission( Day 1);To compare the mortality rate among sepsis patients developing thrombocytopenia at Day 1, Day4, and Day10, after ICU admissionTimepoint: ICU admission( Day 1) with Day 4 and Day 10;To determine the incidence of thrombocytopenia in sepsis patients during ICU stayTimepoint: ICU admission( Day 1) to Day 10 | — |
Countries
India
Contacts
Public ContactSagarika Panda
AIIMS RISHIKESH
Outcome results
None listed