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Comparing efficacy of two different doses of DEXMEDETOMIDINE for supression of haemodynamic responses to laryngoscopy with BIS monitoring

A prospective randomised double blinded study to compare efficacy of two different doses of dexmedetomidine for attenuation of pressor responses to laryngoscopy and endotracheal intubation under bispectral index- controlled general anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/024088
Enrollment
120
Registered
2020-03-19
Start date
Unknown
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z768- Persons encountering health services in other specified circumstances

Interventions

Intervention1: Attenuation of pressor responses to laryngoscopy and endotracheal intubation under bispectral index- controlled general anaesthesia: Haemodynamic changes during laryngoscopy and endotra

Sponsors

JLN Medical College Ajmer
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age group between 18 and 55 years. Body weight 50 to 70 kg. Patients belonging to ASA (American Society of Anaesthesiologists) physical status class-I and II. Patients undergoing elective surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: Patientâ??s refusal. Uncooperative patients. Any known hypersensitivity or contraindication to Dexmedetomidine. History of convulsion, bleeding disorder, severe neurological deficit, thyroid disorder. Patient with history of respiratory, cardiac, hepatic or renal disease (necessitating classification in ASA Class III or above). Patients having a history of significant neurological, psychiatric, or neuromuscular disorders. Anticipated difficult airway which requires >20seconds to intubate.

Design outcomes

Primary

MeasureTime frame
The primary outcome of our study will be to assess haemodynamic changes (HR, SBP, DBP, MAP) from baseline upto 30 min after intubation.Timepoint: Duration of study is around 1 year—

Secondary

MeasureTime frame
secondary outcome will be assessment of sedation of patient using Ramsay Sedation Score (RSS) pre-operatively i.e before infusion with Dexmeditomidine and after completion of infusion. Intraoperative DOSAGE REQUIREMENT OF PROPOFOL for induction will also be noted in our study and the effect of two varying doses of dexmedetomidine on intraoperative DOSAGE REQUIREMENT OF PROPOFOL will be assessed. Any associated SIDE EFFECTS/COMPLICATIONSTimepoint: Duration of study is around 1 year—

Countries

India

Contacts

Public ContactDr Kavita Jain

Jawahar lal nehru medical college, Ajmer, Rajasthan

drkavitajain15@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 9, 2026