Health Condition 1: D330- Benign neoplasm of brain, supratentorial Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Sterofundin: Patients will receive only Sterofundin as the sole intravenous fluid throughout the perioperative period, extending till 6 hours postoperatively.
Intervention2: Plasmalyte
Sponsors
Department of Neuroanaesthesia
Eligibility
Inclusion criteria
Inclusion criteria: ASA physical status I and II aged 18 to 65 years undergoing craniotomy and excision of supratentorial tumours under general anaesthesia at Neurosciences centre, AIIMS, New Delhi.
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate 2. Radiological findings suggesting tumour size >60mm, meningioma, high grade glioma, midline shift 3. Sellar and suprasellar tumours 4. Patients on acetazolamide preoperatively
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in base excess and chloride level in arterial blood gas sampleTimepoint: Basseline Tumor excision Surgery end 6 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Brain relaxation as described by the surgeon on a subjective 4-point scale where 1 denotes perfectly relaxed brain, 2 acceptably relaxed, 3 firm brain and 4 budging brain.Timepoint: After elevation of skull bone flap;Incidence of renal dysfunction by change in neutrophil gelatinase-associated lipocalin (NGAL).Timepoint: 6 hours postoperatively;Other metabolic parameters on ABG.Timepoint: Basseline Tumor excision Surgery end 6 hours postoperatively;Perioperative morbidity such as blood loss and mechanical ventilation more than 24 hours.Timepoint: Intraoperative 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactGirija Prasad Rath
AIIMS, New DElhi
Outcome results
None listed