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Comparison of orally given pregabalin and clonidine in reducing the blood pressure and heart rate response to laryngoscopy and endotracheal intubation in patients undergoing thyroid surgeries

Comparison of oral Pregabalin with Clonidine for attenuating pressor response to direct Laryngoscopy in patients undergoing thyroidectomy-A randomised controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2020/03/023933
Enrollment
60
Registered
2020-03-12
Start date
Unknown
Completion date
Unknown
Last updated
2021-11-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E079- Disorder of thyroid, unspecified

Interventions

Intervention1: PREGABALIN: TAB PREGABALIN 150 MG ORAL 1 HOUR BEFORE INDUCTION OF GENERAL ANESTHESIA, Single dose Control Intervention1: CLONIDINE: TAB CLONIDINE 150 MCG ORALLY 1 HOUR PRIOR TO INDUCTIO

Sponsors

MOSC Medical College Kolenchery
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA I AND II PATIENTS WITH BMI 18 TO 30 UNDERGOING THYROIDECTOMY UNDER GENERAL ANESTHESIA

Exclusion criteria

Exclusion criteria: KNOWN ALLERGY TO STUDY DRUGS THYROID WITH RETROSTERNAL EXTENSION PATIENT REFUSAL FOR PARTICIPATION IN THE STUDY PATIENTS ON LONG TERM TREATMENT WITH ANALGESICS SEDATIVES BETA BLOCKERS AND ANTICONVULSANTS PREGNANT WOMEN

Design outcomes

Primary

MeasureTime frame
To compare oral Pregabalin with Clonidine in blunting the pressor response to direct laryngoscopy and endotracheal intubation by monitoring the changes in heart rate and blood pressure Timepoint: 1;3;5;7;10 minutes after intubation—

Secondary

MeasureTime frame
To assess the effect of oral pregabalin and clonidine on preoperative anxiety and sedation using standard scoring systems. Timepoint: 5 minutes before starting the case ;To evaluate the intra operative hemodynamic profile by monitoring heart rate, blood pressure and postoperative analgesiaTimepoint: 30 minutes interval for 6 hours after surgery—

Countries

India

Contacts

Public ContactSam Phillip

MOSC medical college, Kolenchery

drsam_p@hotmail.com9447209010

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026